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[(2)16.8(7)0(,)21(2)16.8(8,)21(3)16.9(8)0()23.3(4)0(3)]TJ
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T*
[(in)-342.3(hi)20.2(pp)20.9(oc)21(am)17.8(p)13(a)0(l)-342.5(n)13.3(eu)15.2(r)12.2(o)0(a)21.3(n)0(a)21(t)0(o)20.8(m)10.2(y)-349(a)0(n)21(d)-354.3(c)12.5(a)0(n)21(n)0(a)15.8(b)13.7(i)11.7(s)-349.9(us)14.9(e)12.5(,)-351.1(o)13.7(n)0(l)20.2(y)]TJ
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(19)Tj
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T*
[(DA)19.2(T1)-262.4(an)21(d)-276.7(B)14(DN)19.5(F)18.5(a)12.8(f)0(f)18.1(e)0(c)19.8(t)-272.2(th)20.8(e)-277.2(v)13.1(ol)20.6(um)18(e)-272(o)13.7(f)-278(t)12.3(he)-263.5(hi)20.2(p)13(p)0(o)16.4(c)12.5(am)17.8(-)]TJ
0 -1.1847 TD
[(pu)15.7(s)-287.8(a)0(n)21(d)-292.2(i)11.7(t)0(s)-280.7(s)0(u)20.1(b)0(r)20.8(e)0(g)20.4(i)0(o)20.2(n)0(s)-279.7(i)0(n)-280.2(c)0(a)20.1(n)0(n)16.3(a)12.8(bi)20.2(s)-293(u)13(se)19.5(rs)19.3(.)]TJ
1.0036 -1.1795 TD
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(work)Tj
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(19)Tj
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[(parent)-537.7(in)-531.5(cannabis)-537.8(u)1.1(sers)-537.8(versus)-532.6(c).5(ontrols,)]TJ
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T*
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[(,)-300.9(D)3.1(AT1)-303.8(9)1.4(/9R)-303.3(v)1.1(s.10/10R,)-300.9(a).8(nd)-299(BDNF)]TJ
/F12 1 Tf
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(vs.)Tj
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(met)Tj
/F11 1 Tf
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[(allele)-423.6(carriers\),)]TJ
8.2191 0 0 7.3052 418.9605 327.1747 Tm
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[(41)-7.2(,50)]TJ
10.959 0 0 10.959 441.9211 322.2991 Tm
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[(as)-424.1(ele)-4.8(v).9(ated)-423.3(extracellular)]TJ
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[(dopamine)-299.5(levels)-299.8(may)-298.9(m)-1.8(ediate)-299.5(neurotoxic)-299.5(effects.)-300.9(We)]TJ
0 -1.1795 TD
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0 -1.1847 TD
[(would)-459.6(b)1.5(e)-460.2(a).5(ffected)-459.6(by)-454.4(c)-4.9(a).5(nnabis)-455.3(u).8(se)]TJ
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[(c)-5.5(r)-.6(oss-pr)-5.8(oducts)-5.8(.)]TJ
/F5 1 Tf
10.4607 0 0 10.4607 313.0582 244.5731 Tm
/Cs8 cs 1 scn
0 Tc
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(Participants)Tj
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0 0 0 rg
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0 -1.1795 TD
[(community,)-354.9(including)-351.9(30)-350.8(cannabis)-352.9(users)-351.7(and)-354(29)-350.8(con-)]TJ
0 -1.1847 TD
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0 -1.1795 TD
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0 -1.1847 TD
[(\(Table)-300.8(1\).)]TJ
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0 -1.1795 TD
[(interview)-563.6(screening)-559.2(on)-557.5(sociodemographic)-558.3(and)-560.9(sub-)]TJ
0 -1.1847 TD
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0 -1.1795 TD
[(male)-449.2(gender,)-450.3(Caucasian)-443.1(ethnicity,)-450.1(aged)-445.2(1830)-445.1(years,)]TJ
T*
(IQ)Tj
/F6 1 Tf
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(>)Tj
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(90,)Tj
/F6 1 Tf
1.702 0 TD
(<)Tj
/F11 1 Tf
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[(5)-493.6(lifetime)-495.3(use)-500.3(of)-492(psychoactive)-498.7(substances)]TJ
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[(other)-504.7(than)-506.6(cannabis,)-502.2(nicotine,)-508.7(or)-501.7(alcohol.)-503.7(Cannabis)]TJ
0 -1.1795 TD
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f
Q
EMC
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f
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f
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f
BT
/F5 1 Tf
8.9663 0 0 8.9663 59.7543 699.2502 Tm
[(Table)-306.5(1.)-500.5(Sample)-303.4(Sociodemographic,)-306.4(Substance)-305.3(Use)]TJ
0 -1.1128 TD
[(Characteristics)-307.8(and)-302(Total)-306.4(and)-302(Subregional)]TJ
T*
[(Hippocampus)-308.8(Volumes)]TJ
/F2 1 Tf
7.9702 0 0 7.9702 145.7574 660.699 Tm
[(Cannabis)-326.1(users)-2180.6(Controls)-3082.8(t/)]TJ
/F13 1 Tf
16.1112 0 TD
(v)Tj
/F2 1 Tf
5.9774 0 0 5.3127 278.5322 664.2707 Tm
(2)Tj
7.9702 0 0 7.9702 281.707 660.699 Tm
(,)Tj
/F10 1 Tf
.5264 0 TD
(p)Tj
/F8 1 Tf
-28.3743 -2.1055 TD
[(Demographi)12(cs)]TJ
1.003 -1.1239 TD
[(Age)-328.6(\(years\))-6428.6(21.0)-328.7(\(2.3\))-3427.8(22.4)-328.7(\(3.3\))-2339.5(1.84,)-330.9(0.07)]TJ
T*
[(Males)-326.5(\()]TJ
/F9 1 Tf
3.0089 0 TD
(n)Tj
/F8 1 Tf
.8322 0 TD
[([%]\))-6368.3(30)-331.5(\(100\))-3819(29)-331.5(\(100\))-3520.3()]TJ
-4.844 -1.5009 TD
[(Cannabis)-327(use)]TJ
1.003 -1.1239 TD
[(Duration)-320(\(years\))-4963.3(5.7)-326.6(\(2.4\))-4843.3()-5252.4()]TJ
T*
[(Age)-328.6(onset)-329(\(years\))]TJ
.9958 -1.1239 TD
[(First)-330(try)-6954.3(15.0)-328.7(\(1.1\))-3427.8(16.7)-328.7(\(2.0\))-1898.5(2.96,)]TJ
/F6 1 Tf
25.3726 0 TD
(<)Tj
/F8 1 Tf
.5335 0 TD
(0.05)Tj
-25.906 -1.131 TD
[(Regular)-324.3(use)-5229(18.1)-328.7(\(2.0\))-4843.3()-5252.4()]TJ
-.9958 -1.4938 TD
(Joints)Tj
.9958 -1.131 TD
[(Daily)-8594.5(2.5)-326.6(\(1.5\))-4843.3()-5252.4()]TJ
0 -1.1239 TD
[(Past)-328.7(month)-4782.6(86.03)-323.7(\(56.85\))-3823.3()-5252.4()]TJ
T*
[(Past)-328.7(year)-5301.5(987.52)-325.9(\(679.97\))-3313.3()-5252.4()]TJ
T*
(Lifetime)Tj
.9958 -1.1239 TD
[(\(cumulati)11.1(ve\))]TJ
8.8345 1.1239 TD
[(5203)-328.7(\(4192\))-3117(5.1)-326.6(\(11.3\))-1388.5(6.68,)]TJ
/F6 1 Tf
15.7343 0 TD
(<)Tj
/F8 1 Tf
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(0.01)Tj
-28.2818 -2.6247 TD
[(Alcohol)-328.2(use)]TJ
1.003 -1.1239 TD
[(Age)-328.6(of)-327.4(onset)-329(\(years\))-2630.2(15.0)-328.7(\(1.1\))-3427.8(15.7)-328.7(\(1.5\))-1898.5(2.20,)]TJ
/F6 1 Tf
26.3684 0 TD
(<)Tj
/F8 1 Tf
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(0.05)Tj
-26.9019 -1.1239 TD
[(Duration)-291.6(\(years\))-4991.8(5.7)-326.6(\(2.3\))-3940(6.2)-326.6(\(3.1\))-3861.7(ns)]TJ
T*
[(Alcoho)11.8(l)-332.9(\(units/week\))-3056.2(5.3)-326.6(\(3.8\))-3940(3.2)-326.6(\(2.6\))-1898.5(2.35,)]TJ
/F6 1 Tf
26.3684 0 TD
(<)Tj
/F8 1 Tf
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(0.05)Tj
-27.9048 -1.5009 TD
[(Tobacco)-328(use)]TJ
1.003 -1.131 TD
[(Current)-326(smokers)-330.2(\()]TJ
/F9 1 Tf
7.5186 0 TD
(n)Tj
/F8 1 Tf
.5264 0 TD
[(\))-3517.4(2)0(7)-331.5(\(90.0\))-4134.2(9)-329.4(\(31.0\))-1388.5(21.6,)]TJ
/F6 1 Tf
18.5155 0 TD
(<)Tj
/F8 1 Tf
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(0.01)Tj
-27.2789 -1.1239 TD
[(Age)-328.6(of)-327.4(onset)-329(\(years\))-2630.2(16.3)-328.7(\(1.5\))-3427.8(16.3)-328.7(\(2.2\))-3861.7(ns)]TJ
T*
[(D)22.9(u)21.7(r)23.2(a)16.6(t)23.2(i)22.7(o)14.6(n)-308.7(o)21.7(f)-313.6(u)21.7(s)18(e)-310.9(\()17.8(y)19.9(e)23.4(a)23.8(r)16.1(s)25.1(\))-2414.9(4.5)-326.6(\(2.7\))-3940(4.9)-326.6(\(3.3\))-3861.7(ns)]TJ
T*
[(Cigarett)11.7(es)]TJ
.9958 -1.1239 TD
[(smoked)-293.1(daily)-295(\()]TJ
/F9 1 Tf
6.1315 0 TD
(n)Tj
/F8 1 Tf
.5335 0 TD
(\))Tj
3.9905 1.1239 TD
[(6.0)-326.6(\(5.0\))-3940(2.4)-326.6(\(5.9\))-2339.5(1.79,)-330.9(0.08)]TJ
-12.6543 -2.6247 TD
[(Hippocampu)9.2(s)]TJ
1.003 -1.1239 TD
[(Total)-330(volume)-4609(4817.6)-325.9(\(482.0\))-1390.7(4919.7)-325.9(\(465.6\))]TJ
5.9774 0 0 5.3127 278.0787 408.3589 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 395.8865 Tm
[(Subiculum)-5197.9(10700.4)-328(\(879.8\))-878.5(10341.6)-328(\(1076.2\))]TJ
5.9774 0 0 5.3127 278.0787 399.4015 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 386.929 Tm
[(Presubiculum)-4451(7284.6)-325.9(\(549.0\))-1390.7(7246.0)-325.9(\(753.8\))]TJ
5.9774 0 0 5.3127 278.0787 390.444 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 377.9149 Tm
[(CA1)-8436(5566.9)-325.9(\(569.5\))-1390.7(5243.3)-325.9(\(629.8\))]TJ
5.9774 0 0 5.3127 278.0787 381.4865 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 368.9574 Tm
[(CA2/3)-7080.9(16852.4)-328(\(1653.7\))-368.5(15595.6)-328(\(1779.7\))]TJ
5.9774 0 0 5.3127 278.0787 372.529 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 359.9999 Tm
[(CA4/DG)-6802(9385.2)-325.9(\(922.8\))-1390.7(8821.4)-325.9(\(1024.0\))]TJ
5.9774 0 0 5.3127 278.0787 363.5716 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 351.0424 Tm
[(Fimbria)-7501.2(993.2)-323.7(\(219.2\))-1390.7(1123.6)-325.9(\(262.7\))]TJ
5.9774 0 0 5.3127 278.0787 354.5574 Tm
(a)Tj
7.9702 0 0 7.9702 67.748 342.085 Tm
[(Fissure)-7773.1(552.5)-323.7(\(193.34\))-1392.8(537.8)-323.7(\(164.0\))]TJ
5.9774 0 0 5.3127 278.0787 345.5999 Tm
(a)Tj
7.9702 0 0 7.9702 59.7543 330.1227 Tm
[(Genetic)-333.1(polymor)10.5(phism)]TJ
1.003 -1.1239 TD
[(BDNF)-328.3(\()]TJ
/F9 1 Tf
2.9377 0 TD
(n)Tj
/F8 1 Tf
.5264 0 TD
(\))Tj
/F9 1 Tf
-2.4683 -1.1239 TD
(Met)Tj
/F8 1 Tf
11.5517 0 TD
[(10)-6498.6(9)-5521.9(n)0(s)]TJ
/F9 1 Tf
-11.5517 -1.131 TD
(Val/val)Tj
/F8 1 Tf
11.5517 0 TD
[(16)-6242.5(18)]TJ
-12.5476 -1.4938 TD
[(COMT)-323.7(\()]TJ
/F9 1 Tf
3.1582 0 TD
(n)Tj
/F8 1 Tf
.5264 0 TD
(\))Tj
/F9 1 Tf
-2.6888 -1.131 TD
(Met)Tj
/F8 1 Tf
11.5517 0 TD
[(23)-6242.5(22)-5268(ns)]TJ
/F9 1 Tf
-11.5517 -1.1239 TD
(Val/val)Tj
/F8 1 Tf
11.8078 0 TD
6.7525 Tc
(77)Tj
-12.8036 -1.5009 TD
0 Tc
[(DAT)-328(\()]TJ
/F9 1 Tf
2.3544 0 TD
(n)Tj
/F8 1 Tf
.5335 0 TD
(\))Tj
/F9 1 Tf
-1.8921 -1.1239 TD
(9/9R)Tj
/F8 1 Tf
11.5517 0 TD
[(15)-6242.5(13)-5268(ns)]TJ
/F9 1 Tf
-11.5517 -1.1239 TD
(10/10R)Tj
/F8 1 Tf
11.5517 0 TD
[(13)-6242.5(16)]TJ
-12.5476 -1.5009 TD
(COMT)Tj
/F6 1 Tf
2.7101 0 TD
()Tj
/F8 1 Tf
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[(DAT)-335.2(\()]TJ
/F9 1 Tf
2.3616 0 TD
(n)Tj
/F8 1 Tf
.5264 0 TD
(\))Tj
/F9 1 Tf
-5.3135 -1.1239 TD
(Val/val)Tj
/F6 1 Tf
3.0515 0 TD
(+)Tj
/F9 1 Tf
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(10/10R)Tj
/F8 1 Tf
7.9311 0 TD
6.7525 Tc
[(43)1230.6(n)6752.5(s)]TJ
/F9 1 Tf
-11.8078 -1.1239 TD
0 Tc
(Met)Tj
/F6 1 Tf
1.8067 0 TD
(+)Tj
/F9 1 Tf
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(10/10R)Tj
/F8 1 Tf
3.0942 0 TD
(and)Tj
-4.7302 -1.1239 TD
(Val/val)Tj
/F6 1 Tf
3.0515 0 TD
(+)Tj
/F8 1 Tf
.5264 0 TD
(9/9R)Tj
6.978 1.1239 TD
[(10)-6242.5(17)]TJ
/F9 1 Tf
-11.5517 -2.2478 TD
(Met)Tj
/F6 1 Tf
1.8067 0 TD
(+)Tj
/F9 1 Tf
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(9/9R)Tj
/F8 1 Tf
8.9199 0 TD
[(14)-6498.6(9)]TJ
/F9 1 Tf
-11.5517 -1.131 TD
(Met)Tj
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5.9774 0 0 5.3127 68.7685 127.5023 Tm
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T*
[(pal)-302(subregion)11.5(s.)]TJ
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[(CA,)-220.4(cornu)-221.8(ammonis;)-216(DG,)-223.4(dentate)-220(gyrus;)-228(BDNF,)-216.7(brain-derived)-211.5(neurotro-)]TJ
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[(phic)-564.5(factor;)-566.4(COMT,)-567.7(catechol-O)10.5(-methyltra)11.3(nsferase;)-565.8(ns,)-563.2(not)-569.6(signicant;)]TJ
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[(VNTR,)-299.3(variable)-291.8(number)-289.3(of)-299(tandem)-294.4(repeats;)-293.8(UTR,)-300.4(untranslat)10.5(ed)-296.6(region.)]TJ
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(Batalla,)Tj
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[(et)-300.9(al.;)-297.1(Cannabis)-298.5(and)-292.6(Cannabinoi)9(d)-305.1(Research)]TJ
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[(2018,)-295.3(3.1)]TJ
-21.0051 -1.2021 TD
[(http://online)10(.liebertpub.com)7(/doi/10.10)9.8(89/can.2017)10.5(.0021)]TJ
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[(as)19.8(e)-204.8(\()11.9(I)12.3(n)0(v)16.1(i)11.7(t)12.3(r)0(o)20.8(g)0(e)20.4(n)0(\))14.9(,)-201(a)12.8(n)0(d)-196.1(\()11.9(i)11.7(v)0(\))-192.3(5)0(0)-149.1(n)13.3(g)-204.2(o)0(f)-191.9(g)13.1(en)15.5(o)13.7(m)10.2(i)11.7(c)-204.8(DN)19.5(A)-197.6(a)0(s)-192.3(t)0(e)19.6(m)10.2(-)]TJ
0 -1.1795 TD
[(pl)19.9(at)19.9(e)12.5(.)-728.7(A)14.5(m)10.2(pl)19.9(i)20.2(ca)20.1(ti)18.8(on)-712.7(c)12.5(o)0(n)16.7(d)13(it)18.8(i)11.7(o)0(n)16.7(s)-722.4(i)11.7(n)0(c)20.6(l)0(u)19.9(d)0(e)20.3(d)-726.7(a)12.8(n)-726.4(i)11.7(n)0(i)19.8(t)12.3(ia)19.3(l)]TJ
T*
[(de)20.3(na)21(tu)20.2(ra)19.8(ti)18.8(on)-190.2(s)12.2(t)0(e)19.6(p)-199.1(of)-191.9(5)-157.3(m)10.2(i)11.7(n)-198.8(at)-192.2(9)13.4(5)]TJ
/F6 1 Tf
12.2759 0 TD
()Tj
/F11 1 Tf
.3828 0 TD
[(C,)-191.7(f)11.7(o)0(l)20.6(l)12(ow)18.2(e)12.5(d)-199.1(by)-190.5(35)-190.5(c)12.5(y)0(c)20.4(l)0(e)19.4(s)]TJ
-12.6588 -1.1847 TD
[(of)-388.5(3)13.4(0)-157.3(se)19.5(c)-396.2(a)0(t)-388.8(9)0(5)]TJ
/F6 1 Tf
5.9181 0 TD
()Tj
/F11 1 Tf
.388 0 TD
[(C)14.5(,)-397.6(40)-149.1(s)12.2(e)0(c)-388.9(a)0(t)-388.8(5)13.4(8)]TJ
/F6 1 Tf
6.0009 0 TD
()Tj
/F11 1 Tf
.3828 0 TD
[(C,)-388.3(45)-143.9(se)19.5(c)-401.4(a)12.8(t)-396.4(7)0(2)]TJ
/F6 1 Tf
6.0009 0 TD
()Tj
/F11 1 Tf
.388 0 TD
[(C,)-388.3(a)12.8(n)0(d)]TJ
-19.0787 -1.1795 TD
.1573 Tc
[(5m)167.5(i)169(n)-341.5(a)170.1(t)-342.5(7)170.7(2)]TJ
/F6 1 Tf
4.8886 0 TD
0 Tc
()Tj
/F11 1 Tf
.3828 0 TD
[(C.)-486.6(W)11(e)-499.7(us)20.1(ed)-486.6(a)-499.3(t)12.3(ot)20.8(al)-487.3(r)12.2(e)0(a)14.9(c)12.5(t)12.3(i)0(o)20.2(n)-498.8(vo)21.6(l)12(u)0(m)18(e)-499.6(o)13.7(f)]TJ
-5.2715 -1.1847 TD
(10)Tj
/F14 1 Tf
1.1019 0 TD
(l)Tj
/F11 1 Tf
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[(L.)-373.6(Af)21(te)19.6(r)-386.1(P)13.6(CR)18.1(,)-382.1(w)0(e)-371(d)0(e)20.3(t)0(e)19.6(c)0(t)19.6(e)0(d)-372.8(t)0(h)20.8(e)-385.8(pr)20.1(od)21.6(uc)20.3(ts)-373.8(of)-373(al)19.7(l)12(e)0(l)19.3(i)0(c)19(-)]TJ
-1.6451 -1.1795 TD
[(sp)20.1(ec)19.8(i)20.2(c)-484.1(a)12.8(m)10.2(p)0(l)19.9(i)11.7(c)15.8(a)12.8(t)12.3(io)20.2(ns)-471.1(\(a)19.5(ll)18.9(el)19.3(e)]TJ
/F12 1 Tf
12.1156 0 TD
[(9/)19.5(9R)]TJ
/F11 1 Tf
1.8054 0 TD
.4804 Tc
[(,4)493.8(5)480.4(0)331.3(b)494.1(p)480.4(,)7.9(a)480.4(n)501.4(d)-3.2(a)493.2(l)480.4(l)499.3(e)480.4(l)499.7(e)]TJ
/F12 1 Tf
-13.921 -1.1847 TD
0 Tc
[(10)20.3(/1)19.5(0R)]TJ
/F11 1 Tf
2.7159 0 TD
[(,)-237.2(4)13.4(80)-149.1(b)13.7(p)0(\))-223.4(t)0(h)20.8(r)0(o)20.8(u)0(g)21(h)-234.6(an)-222.2(au)20.6(to)20.8(m)10.2(a)0(t)19.9(i)0(c)-224.1(A)0(B)18.1(I)-230.9(37)21.6(30)21.7(XL)-225.9(c)12.5(a)0(p)20.7(-)]TJ
-2.7159 -1.1795 TD
[(i)11.7(l)0(l)18.9(a)0(r)19.8(y)-214.5(s)12.2(e)0(q)15.5(u)13(en)20.7(ce)19.8(r.)-209.5(D)15.1(a)0(t)19.9(a)-214.8(we)22.1(re)-208.1(a)12.8(n)0(a)21(l)0(y)20(z)0(e)19.8(d)-214.6(th)20.8(ro)20.8(ug)15.8(h)-213.9(G)14.8(en)15.5(e)12.5(M)10.7(ap)20.7(-)]TJ
0 -1.1847 TD
[(pe)20.3(r)-349.9(S)0(o)16.1(f)11.6(t)12.3(w)0(a)17.3(r)12.2(e)-354.8(v)13.1(3.)19.3(5)-348.7(\()0(A)16.1(p)13(pl)19.9(i)11.7(e)0(d)-341.8(B)0(i)20.5(o)0(s)20.8(y)0(s)20.2(t)0(e)19.6(m)10.2(s\))19(.)-351(S)0(e)20.1(q)0(u)16.1(e)12.5(nc)20.6(es)-342.6(f)11.7(o)0(r)]TJ
0 -1.1795 TD
[(ge)20.4(no)21.9(ty)20.2(pi)19.5(ng)-278.8(BD)18.7(NF)-277.4(ar)19.8(e)-292.7(d)0(e)20.3(s)0(c)19.5(r)12.2(ib)20.2(ed)-284.9(i)11.7(n)-286.7(de)15.2(t)12.3(a)0(i)19.3(l)-288(el)19.3(se)19.5(wh)23.3(er)19.5(e.)]TJ
8.2191 0 0 7.3052 285.9023 508.4786 Tm
(53)Tj
10.959 0 0 10.959 72.9637 490.677 Tm
[(Af)15.8(t)12.3(e)12.5(r)-199.9(g)13.1(en)20.7(ot)20.8(yp)21(e)-199.6(d)13(et)19.6(er)19.5(m)10.2(i)11.7(na)15.8(t)12.3(i)11.7(on)21.9(,)-195.9(t)0(h)20.8(e)-199.6(s)12.2(a)0(m)17.8(p)13(l)12(e)-199.6(w)14.8(a)0(s)-187.1(d)0(i)19.5(v)0(i)19.6(d)0(e)20.3(d)]TJ
-.9984 -1.1847 TD
[(i)11.7(n)0(t)20.5(o)-260.5(s)12.2(u)0(b)21.6(g)0(r)20.2(o)0(u)16.4(p)13(s)-256.8(b)0(a)21.3(s)0(e)19.5(d)-256(on)-247.1(\(i)18.4(\))-257.1(C)0(O)18.9(M)10.7(T)-255.1(p)0(o)21.6(l)12(ym)18.1(or)20.8(ph)21.5(is)18.7(m)-258.8(\()11.9(i)11.7(.)0(e)18.4(.)11.1(,)]TJ
/F12 1 Tf
0 -1.1795 TD
[(va)20.7(l/)18.2(v)12.8(a)0(l)]TJ
/F11 1 Tf
2.7728 0 TD
[(ho)17(m)15.3(o)0(z)15.9(y)13.1(go)21.6(te)-182.1(an)21(d)]TJ
/F12 1 Tf
6.663 0 TD
-.0112 Tc
(met)Tj
/F11 1 Tf
1.4485 0 TD
0 Tc
[(-)12.6(a)0(l)19.7(l)12(el)19.3(e)-194.4(c)12.5(ar)19.8(ri)18.7(e)12.5(r)0(s)-182.5(i)0(n)19.8(c)0(l)19.3(u)0(d)20.9(i)0(n)19.8(g)]TJ
/F12 1 Tf
9.4876 0 TD
-.0128 Tc
[(va)-12.8(l)6.5(/)]TJ
-20.372 -1.1847 TD
-.0112 Tc
(met)Tj
/F11 1 Tf
1.8727 0 TD
-.0128 Tc
[(an)-12.8(d)]TJ
/F12 1 Tf
1.8934 0 TD
-.0112 Tc
(met)Tj
/F11 1 Tf
1.8675 0 TD
0 Tc
[(ho)17(m)10.2(o)13.7(zy)20.4(go)21.7(us)20.1(\);)-406.4(\(i)18.4(i)11.7(\))-417.5(D)15.1(A)0(T)18(1)-416(p)13(o)0(l)20.6(y)0(m)18.1(o)13.7(rp)20.1(hi)20.2(sm)]TJ
-5.6336 -1.1795 TD
[(\(i)18.4(.)11.1(e)0(.)18.4(,)]TJ
/F12 1 Tf
1.9658 0 TD
[(9/)19.5(9R)]TJ
/F11 1 Tf
2.1572 0 TD
-.0128 Tc
[(an)-12.8(d)]TJ
/F12 1 Tf
1.821 0 TD
[(10)-12.8(/)6.7(1)-12.8(0)7.5(R)]TJ
/F11 1 Tf
3.0677 0 TD
0 Tc
[(al)19.7(le)19.4(l)12(e)-344.5(ca)20.1(rr)19.3(i)11.7(e)0(r)19.5(s)0(\))19(;)-345.9(\()11.9(i)11.7(ii)18.2(\))-345(B)14(DN)19.5(F)-343.9(p)0(o)21.6(l)12(y-)]TJ
-9.0117 -1.1847 TD
-.0111 Tc
[(mo)-11.1(r)9.7(p)-11.1(h)10.4(i)-11.1(s)7.6(m)-233.7(\(i)-11.1(.)6.5(e)-11.1(.)7.3(,)]TJ
/F12 1 Tf
6.1612 0 TD
0 Tc
[(va)20.7(l/)18.2(va)20.7(l)]TJ
/F11 1 Tf
2.809 0 TD
[(h)13.7(o)0(m)18.7(o)13.7(zy)20.4(go)21.6(te)-213.2(an)15.8(d)]TJ
/F12 1 Tf
6.72 0 TD
-.0102 Tc
[(me)-10.2(t)]TJ
/F11 1 Tf
1.4485 0 TD
0 Tc
[(-)12.6(a)0(l)19.7(l)0(e)19.4(l)12(e)-225.5(c)12.5(ar)19.8(ri)18.7(-)]TJ
-17.1387 -1.1795 TD
-.02 Tc
[(e)-20(r)-.5(s)-421.6(i)-20(nc)-20(lu)-20(di)-20(ng)]TJ
/F12 1 Tf
5.6181 0 TD
-.0115 Tc
[(va)-11.5(l)7.8(/).5(me)-11.5(t)]TJ
/F11 1 Tf
3.2953 0 TD
-.0128 Tc
[(an)-12.8(d)]TJ
/F12 1 Tf
1.8779 0 TD
-.0102 Tc
[(me)-10.2(t)]TJ
/F11 1 Tf
1.8623 0 TD
0 Tc
[(h)13.7(o)0(m)18.7(o)13.7(zy)15.2(g)13.1(o)0(u)21.6(s)0(\))19(;)-402.8(an)21(d)-406(\()11.9(i)11.7(v)0(\))]TJ
-12.6536 -1.1847 TD
[(co)21(m)10.2(b)0(i)20.2(n)0(a)21(t)0(i)18.8(o)0(n)21.9(s)-717.2(of)-709.2(DA)24.4(T1)17()13.4(C)0(O)18.9(M)10.7(T)-715.5(v)0(a)20.7(r)0(i)18.7(a)0(n)21(t)0(s)-710.1(a)12.8(ss)19.3(oc)21(i)11.7(a)0(t)19.9(e)0(d)]TJ
0 -1.1795 TD
-.0202 Tc
[(with)-301.4(di)-3.3(ff)-3.4(erent)-297.6(d)-2(opamine)-302.6(a)2.9(vai)-3.3(l)2.2(abili)-3.3(t)2.4(y)-302(l)2.2(evels)-302.8(\()2.1(Table)-302.6(1)3.6(\).)]TJ
8.2191 0 0 7.3052 282.0472 391.918 Tm
-.0246 Tc
[(54)6.1(56)]TJ
10.959 0 0 10.959 62.022 374.0597 Tm
-.0249 Tc
[(The)-317.6(d)3.6(istribution)-316.8(o)-.8(f)-318.5(C)0(OMT)4.5(,)-319(DAT1,)-313.9(B)-.6(DNF,)-319(and)-317.1(C)0(OMT)]TJ
T*
-.0252 Tc
[(DAT1)-477.4(genetic)-478.3(p)-1.8(olymorphism)-475.5(w)0(as)-478.6(in)-477.4(HardyWeinberg)]TJ
T*
-.0245 Tc
[(eq)4.4(uilibrium.)]TJ
/F8 1 Tf
10.4607 0 0 10.4607 62.022 322.2991 Tm
/Cs8 cs 1 scn
0 Tc
[(MRI)-296.9(data)]TJ
/F11 1 Tf
10.959 0 0 10.959 62.022 309.3164 Tm
0 0 0 rg
[(MRI)-201.1(images)-196.6(were)-201.5(acquired)-199(with)-201(a)-199.3(1.5T)-201.7(Signa)-200.2(Excite)-198.8(sys-)]TJ
T*
[(tem)-322(\(General)-327.3(Electric,)-324.1(Milwaukee,)-325.9(WI\))-321.8(equipped)-327.3(with)]TJ
0 -1.1847 TD
-.0193 Tc
[(an)-249.1(eight-)3.6(cha)3.8(nne)3.5(l)-255.6(p)4.1(ha)3.8(sed)4.1(-)-1.6(a)3.8(r)-1.9(ray)-249.3(h)-.4(ea)3.8(d)-254.6(c)3.5(oil.)-251.4(High-)3.6(r)-1.9(e)3.5(s)-1.9(o)4.8(l)-2.1(ution)]TJ
0 -1.1795 TD
-.0203 Tc
[(T1-weighted)-353.9(a)2.8(natomical)-354.9(i)1.7(ma)]TJ
11.1482 0 TD
-.0215 Tc
[(ge)-3.8(s)-350.7(w)-1.5(e)-3.8(r)1.1(e)-355.6(o)2.6(bt)-4(ai)-4.6(ne)-3.8(d)-349.9(b)-2.6(y)-355(u)1.9(s)-4.1(i).5(ng)]TJ
-11.1482 -1.1847 TD
-.0194 Tc
[(a)-689.5(t)3.2(hree)3.4(-dimen)4.3(siona)3.7(l)-690.2(fast)-690(spo)4.7(i)-2.5(led)-684.1(g)-1.1(ra)3.7(dient)-684.8(i)2.6(nve)3.4(r)-2(sio)4.7(n)-.9(-)]TJ
0 -1.1795 TD
-.0189 Tc
[(re)3.9(co)5.2(very)-419.6(pre)3.9(p)-.7(a)4.2(r)-1.5(ed)-419.7(sequ)4.5(enc)3.9(e)-420.3(with)-419.1(130)-419.3(co)5.2(ntig)4.6(uou)4.5(s)-425.7(slice)3.9(s)]TJ
T*
-.0219 Tc
[(\()-4.8(T)2.4(R,)-523(11)-3.3(.8)-168.9(ms)-4.5(ec)-4.2(;)-523(T)2.4(E,)-523(4.)-5.7(2)-168.9(m)3.8(s)-4.5(e)-4.2(c;)-523(i)-5(p)-521(a)1.2(n)-3.4(g)-3.6(le)-4.2(,)-517.8(1)-3.3(5)]TJ
/F6 1 Tf
17.8009 0 TD
0 Tc
()Tj
/F11 1 Tf
.3725 0 TD
.5011 Tc
[(;)520(e)523.9(l)518.3(d)7.2(o)520(f)]TJ
-18.1734 -1.1847 TD
-.0216 Tc
[(vie)-3.9(w)-1.6(,)-331.3(3)2.2(0)-168.6(c)-3.9(m;)-331.3(pi)-4.7(xe)-3.9(l)-330.3(m)-1.1(at)-4.1(ri)-4.7(x,)-331.3(256)]TJ
/F6 1 Tf
11.7948 0 TD
0 Tc
()Tj
/F11 1 Tf
.6932 0 TD
-.0193 Tc
[(256)4.5(;)-329(a)-1.3(nd)-327(slice)-327.5(t)3.3(hickn)4.4(e)-1.6(ss,)]TJ
-12.488 -1.1795 TD
-.0207 Tc
[(1.2)-167.7(mm\).)]TJ
.9984 -1.1847 TD
0 Tc
[(Images)-330.5(were)-325.6(transferred)-333.8(to)-325.8(a)-328.6(Linux)-328.7(workstation)-323.4(for)]TJ
-.9984 -1.1795 TD
[(preprocessing)-813.5(including)-812.3(reorientation,)-807.6(resizing)-816.4(to)]TJ
0 -1.1847 TD
(1)Tj
/F6 1 Tf
.6466 0 TD
()Tj
/F11 1 Tf
.7191 0 TD
(1)Tj
/F6 1 Tf
.6415 0 TD
()Tj
/F11 1 Tf
.7191 0 TD
[(1)-167.6(m)0(m)-217.7(resolution,)-224.3(and)-219.5(alignment)-225.1(to)-217.1(the)-225.4(Montre)]TJ
18.0026 .0414 TD
()Tj
.4035 -.0414 TD
(al)Tj
-21.1324 -1.1795 TD
[(Neurological)-404.7(Institute)-400.2(standard)-405.3(template)-399.1(\(www.fmrib)]TJ
0 -1.1847 TD
[(.ox.ac.uk/fsl\).)-444.4(The)-435.9(same)-438.6(investigator)-438.8(\(A.B.\))-442.9(manually)]TJ
0 -1.1795 TD
[(delineated)-479.6(the)-478.9(hippocampus)-476.8(using)-479.8(Analyze)-478.3(software)]TJ
0 -1.1847 TD
[(\(version)-240.8(9.0;)-235.6(Mayo)-239.4(Clinic,)-233.9(Rochester,)-240.7(MN\),)-236.1(while)-235.3(being)]TJ
0 -1.1795 TD
[(blind)-432.8(to)-434.4(group)-431.5(membership.)-436.2(Tracing)-433(was)-430.9(performed)]TJ
T*
[(on)-324.7(coronally)-324.3(displayed)-326.3(MRI)-325.2(slices,)-324.5(from)-324.7(the)-323.7(caudal)-327.4(to)]TJ
0 -1.1847 TD
[(the)-313.3(rostral)-310.8(portion)-313.5(of)-316.1(the)-308.1(brain,)-318.3(based)-308.2(on)-314.4(a)-313.1(previously)]TJ
0 -1.1795 TD
[(validated)-331.7(protocol.)]TJ
8.2191 0 0 7.3052 144.2267 68.1449 Tm
(48,57)Tj
10.959 0 0 10.959 165.3732 63.2692 Tm
[(Hippocampal)-331(boundaries)-332.2(were)]TJ
13.4761 57.9085 TD
(set,)Tj
/F12 1 Tf
1.6347 0 TD
(medially)Tj
/F11 1 Tf
3.3522 0 TD
[(,)-335.5(b)0(y)-335.3(the)-328.8(cerebral)-334.1(spinal)-338.8(uid)-331.4(\(CSF\))-334.2(of)-336.8(the)]TJ
-4.9869 -1.1847 TD
[(uncal)-215.7(cistern;)]TJ
/F12 1 Tf
5.4784 0 TD
(laterally)Tj
/F11 1 Tf
3.1918 0 TD
[(,)-216.5(b)0(y)-211.1(the)-215(CSF)-213.2(in)-212.9(the)-215(temporal)-211.7(horn)]TJ
-8.6702 -1.1795 TD
[(of)-533.3(the)-530.6(lateral)-534.1(ventricle;)-533.8(and)]TJ
/F12 1 Tf
12.2966 0 TD
(inferiorly)Tj
/F11 1 Tf
4.1437 0 TD
[(by)-531.9(the)-530.6(para-)]TJ
-16.4403 -1.1847 TD
[(hippocampal)-642.8(white)-638.6(matter)-641.7(running)-639.4(medially)-642.5(from)]TJ
0 -1.1795 TD
[(the)-271.9(temporal)-273.8(horn)-267.8(of)-274.7(the)-271.9(lateral)-270.3(ventricle.)-270(We)-271.4(used)-275.2(the)]TJ
0 -1.1847 TD
[(protocol)-434.8(developed)-427.8(by)-433.6(Watson)-431.7(et)-430.5(al.)-429.7(to)-434.4(separate)-432.5(the)]TJ
0 -1.1795 TD
[(hippocampus)-300.9(from)-298.9(the)-303(amygdala.)]TJ
8.2191 0 0 7.3052 461.4802 625.0392 Tm
(58)Tj
10.959 0 0 10.959 324.0566 607.2377 Tm
[(Intraclass)-532.3(correlation)-533.5(coefcients)-528.8(\(absolute)-532.4(agree-)]TJ
-1.0036 -1.1847 TD
[(ment\))-612.3(were)-610.1(computed)-608.5(to)-610.3(assess)-613.9(tracing)-610.5(reliability,)]TJ
0 -1.1795 TD
[(based)-308.2(on)-304(10)-304.3(randomly)-303.1(selected)-304(images.)-304.5(Intrarater)-304.5(reli-)]TJ
0 -1.1847 TD
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T*
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-16.8697 -1.1847 TD
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0 -1.1847 TD
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0 -1.1847 TD
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1.0036 -1.1795 TD
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0 -1.1795 TD
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22.912 57.9085 TD
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[(COMT)-246.6(a)-4.6(n)1.1(d)-247.5(c)-4.9(anna)-4.6(bis)-248.3(a)-4.6(s)-248.3(f)-.5(ac)-4.9(tor)-5.1(s)0(\))-248.6(i)-.5(n)-252.3(c).3(anna)-4.6(bis)-248.3(u)-4.3(se)-4.9(rs)-248.3(re)-4.9(l-)]TJ
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[(ati)-5.3(v)1.3(e)-356.2(t).5(o)-355(n)-3.6(onus)-4.7(ers)-4.7(,)-352.5(whe)-4.5(n)-355.4(cont)-4.7(roll)-4.9(ing)-355.6(f)-5.3(or)-356.5(COMT)-354.8(gene)]TJ
0 -1.1795 TD
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[(polymorphism)-450.9(and)-453.2(I)1.3(CV)-452.1(\(Supplementary)-453.1(Table)-453.7(S)1.8(1\);)]TJ
0 -1.1847 TD
[(this)-562.7(i)-4.6(s)-562.7(alongside)-567.7(d)-3.2(ose-depe)]TJ
11.7897 0 TD
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[(nd)-4.7(ent)-569.3(r)-.4(e)-5.3(l)-.6(at)-5.5(ion)-4.4(s)-.4(hips)-569.4(be)-5.3(-)]TJ
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[(tween)-265.2(th)4.2(e)-266(v)3.6(olu)3.5(m).7(e)-266(o)4.2(f)-266.8(v)3.6(ariou)3.5(s)-266.3(sub)4.2(r)-2.4(eg)3.6(io)4.2(ns)-261.1(an)3.8(d)-265.5(c)3(an)3.8(na)3.3(bis)]TJ
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[(monthly/yearly)-333.1(joints)-334(\()]TJ
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[(0.)-7.5(25)-5.2(,)]TJ
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[(o)4.8(f)-209.4(dop)4.1(a)-1.3(mine)-208.6(av)4.2(aila)3.8(bility)-207.9(\(F)]TJ
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[(4.)-7.6(93)-5.2(,)]TJ
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